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Scientist I

Job Description:

The NanoString nCounter digital molecular barcoding technology enables highly multiplexed, quantitative measurement of analytes of interest (DNA, RNA, miRNA, or protein) from a wide variety of sample formats with easy to use experimental protocols. The Applications team is seeking a highly motivated Scientist I to leverage the NanoString platform to molecularly characterize biological samples to support collaborations and internal development efforts. This person will be responsible for performing experiments independently (including preparing samples, running nCounter and additional assays, and analyzing multiplexed, multi-analyte data) and working with the team to interact with collaborators and prepare results for presentation and publication. This person will be expected to have subject expertise in immunology or oncology and a working knowledge of immuno-oncology therapeutic strategies. We estimate that this position will require 70% benchwork/30% deskwork.

Essential Functions:

  • Purify DNA, RNA, miRNA, and protein from FFPE tissue sections, frozen tissue samples, cryopreserved cells, and biological fluids (e.g. whole blood or plasma)
  • Perform molecular profiling using the nCounter reagents
  • Perform supportive assays to validate NanoString results, including western blots, ELISA, flow cytometry, qPCR, IHC, etc
  • Perform data analysis with the NanoString nSolver package and advanced analysis tools
  • Maintain excellent lab records, participate in weekly lab meetings, communicate with collaborators by email, phone, and in person, work closely with a team of scientists and technicians to achieve goals

Requirements (Education, Experience, Specific Skills):

  • Ph.D. in immunology, oncology, molecular and cellular biology, biochemistry, genetics, or related field
  • Familiarity and experience with molecular biology, cell culture of primary cells and cell lines, and tissue handling
  • Familiarity with a statistical analysis package is strongly preferred but not required
  • Experience in the life science industry is preferred but not required
  • Post-doctoral work in a relevant field preferred but not required
  • Ability to work both independently and as member of a project team
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