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Engineer, Optics and Automation

Job Summary:

We are seeking an Engineer to join our Research and Development group.  In this role you will work on the development of instrumentation and consumables for new genomic tools.  See recently released Sprint TM (http://nanostringsprint.com/). In particular, this position is focused on the development of hardware related to recently announced technologies: Digital IHC enabling spatial multiplexing on tissue slices; and the Hyb & Seq TM technology (NGS), a novel single-molecule hybridization-based sequencing chemistry. The work is highly interdisciplinary and will involve working closely with biologists, software engineers, and external OEM manufacturers.  The applicant will be expected to contribute to the development of instrument/consumable prototypes for feasibility and aid in the testing of these systems. Additionally, the applicant will be expected to work with OEM partners and assist in the development of the new systems up to and through commercialization and transfer to manufacturing. The applicant will be expected to have strong verbal and written communication skills and will be expected to manage communication with OEM partners.   

Essential Functions:

  • Develop instrument systems
  • Design hardware related to imaging/optics
  • Automation of motion, imaging, and fluidic control

Requirements (Education, Experience, Specific Skills):

  • Degree in mechanical, optical, electrical, bioengineering, physics, bio-physics or related field
  • PhD. + 2-4, M.S + 4-6, or B.S. + 6-10 years experience working in the genomics and proteomics and imaging tools industry
  • Experience with design of optical systems
  • Experience with optics and fluorescent microscopy
  • Experience with optics modeling software (Zemax)
  • Instrument prototyping through development and assembly of breadboard systems
  • Automation of repetitive activities through script-level programing and/or .net.
  • Knowledge of image analysis programs and/or programming skills
  • Automation of instrument control and image acquisition
  • Strong engineering or biophysics background in the design and analysis of mechanical, chemical, and biological systems
  • A hands-on orientation toward experimentation and rapid prototype development
  • Wet bench skills
  • Ability to carry out experiments to verify performance of designs
  • Ability to work both independently and closely in collaboration with a core team
  • Excellent verbal and written communication skills

Additional qualifications include:

  • Experience designing mechanical components for optic assemblies
  • Understanding of fluidics/microfluidics
  • Experience with design/selection of hardware to control microfluidics: pumps, valves, and manifolds.
  • Experience with hardware/consumable development for genomics or fluidics
  • Flow cell design and fabrication
  • Experience operating machine shop equipment: Mill, lathe, laser cutter, 3D printer, etc.
  • Experience with imaging and assays involving tissue preparations, especially FFPE (formalin fixed paraffin embedded) tissue.
  • Extensive experience with bright field and fluorescent microscopy applied to tissue and cellular imaging.
  • Experience with digital pathology/immunohistochemistry slides

 

 

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