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Scientist/Engineer - Automated Microfluidic Sample Prep (Hyb & Seq)

Job Description:

We are seeking a Scientist or Engineer to join our Research and Development group.  In this role you will work on the development of new genomic tools that consist of instrumentation, consumables, and chemistry. In particular, this position is focused on the development of the recently announced Hyb & Seq TM technology (NGS), a novel single-molecule hybridization-based sequencing chemistry. The work is highly interdisciplinary will involve working closely with biologists, scientists, software engineers, and external OEM manufacturers.  The applicant will be expected to have strong verbal and written communication skills and will be expected to manage communication with OEM partners.  The position will involve development of chemistry, consumables and hardware as well as extensive wet bench work. The applicant will be expected to automate Hyb and Seq sample prep, and optimize cartridge designs driven by experimental results to deliver the best performance of the system.

Essential functions:

  • Develop sample prep automation for the Hyb and Seq chemistry
  • Experimental testing of designs and purification/concentration strategies
  • Microfluidics design and development


  • PhD. in bioengineering, chemical engineering, physics, bio-physics, molecular biology or related field (more experienced B.S. or M.S. considered)
  • 5-10 years experience  
  • 3-6 years experience developing commercial products
  • Take initiatives to conceive, design and carry-out hypothesis driven feasibility experiments, understanding both theoretical and practical aspects of the experimental design
  • Experience with sample prep automation (such as liquid biopsy, FFPE, cell lysate, and RNA/DNA extraction etc)
  • Experience developing assays with low level sample input
  • Strong wet bench, and assay development skills related to consumable cartridge development
  • Strong knowledge of bio lab tools
  • Experience with sequencing technologies
  • A hands-on orientation toward experimentation and prototype development
  • Automation through script-level programing
  • Ability to work both independently and closely in collaboration with a core team
  • Excellent verbal and written communication skills
  • Knowledge of microfluidic cartridge fabrication techniques

Additional qualifications include:

  • Experience with hardware/consumable development for genomics or fluidics
  • 3D CAD expertise (preferably in SolidWorks)
  • Experience with commercial microfluidic applications
  • Experience with design/selection of hardware to control microfluidics: pumps, valves, and manifolds.
  • Understanding of microscopy techniques
  • Experience with nucleic acid chemistry
  • Experience with magnetic bead based purification techniques and automated products
  • Experience with fluorescence assays and techniquesExperience with statistical analysis of complex data sets


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