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Senior Scientist, NGS Assay Development (Hyb & Seq)

Job Summary:

NanoString is seeking an experienced and technology-savvy molecular biologist or biochemist, to join our Research & Development group.  This position will have a leading role in developing sequencing based assays using Hyb & SeqTM, a novel single-molecule hybridization-based next generation sequencing (NGS) technology.  S/he will lead NGS assay development by interacting and coordinating with a highly interdisciplinary group of technologists to create industry-leading assay products.  The successful candidate must be prepared to be a hands-on experimentalist while guiding a team in wet-lab driven research to create innovative solutions to development hurdles.  Candidates must have strong analytical skills, strong oral and written communication skills, and a track record of building NGS panel products.

Essential Duties:

  • Apply advanced and expert scientific and product knowledge to NGS assay development projects
  • Contribute to assay product conceptualization working closely with business analyst and strategic marketing specialists
  • Establish sample preparation, quality and input requirements and assay workflows
  • Conceive, design and carry-out experiments for fast development of prototype panels for feasibility testing
  • Collaborate with analysts and programmers to develop a bioinformatics analysis pipeline
  • Design and implement assay studies to test and refine both newly developed and/or existing genomics analysis tools and pipelines
  • Work interactively with biophysicists, nucleic-acid chemists, fluorescence imaging specialists, and hardware and software engineers for full system development

Requirements:

  • Ph.D. in Life / Physical Sciences
  • 7+ years of combined industry and post-doctoral work experience in NGS, with significant portion dedicated to NGS panel assay development
  • Extensive hands-on, state-of-the-art molecular biology experience
  • Knowledge of nucleic acid characterization techniques, especially hybridization-based assays
  • Experience working with clinically relevant sample types such as FFPE, whole blood and plasma
  • Experience in cancer genomics (knowledge of oncogenic pathways) and/or infectious disease genomics
  • Expert in navigating and extracting information from publicly available databases (NCBI, UCSC, Ensembl, COSMIC, etc.)
  • Familiarity with commonly used algorithms for alignment and variant calling (SNV, InDel, CNV, Fusion, etc.)
  • Experience analyzing and interpreting NGS data from tumor and/or liquid biopsy samples
  • Experience working with NGS bioinformatics teams

 Additional Desirable Qualifications include:

Experience working with microfluidic devices
Experience leading small teams for assay development 

Other:

  • See benefits at NanoString
  • NanoString is an EOE
  • NanoString participates in E-Verify. E-Verify is a web-based system that allows an employer to determine an employee's eligibility to work in the US using information reported on an employee's Form I-9. The E-Verify system confirms eligibility with both the Social Security Administration (SSA) and Department of Homeland Security (DHS). For more information, please go to the USCIS E-Verify website.

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