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Bioinformatics Scientist II (Hyb & Seq)

Job Summary:

NanoString is seeking an experienced and technology-savvy Bioinformatics Scientist/Developer to join our Research & Development group.  This position will have a leading role in developing NGS tools and pipelines for use with Hyb & SeqTM, a novel single-molecule hybridization-based next generation sequencing (NGS) technology.  S/he will collaborate and interact with a highly interdisciplinary group of technologists to create analysis methods and tools for industry-leading assay products.  The successful candidate must have broad knowledge of public and commercially available tools and pipelines for use with NGS platforms.  Candidates must have strong analytical skills, strong oral and written communication skills, and a track record of developing novel tools and integrating existing tools into NGS analysis solutions.

Essential Functions:

  • Apply advanced and expert scientific and programming knowledge to NGS software and pipeline development
  • Contribute to assay product development working closely with bioinformatics, business analyst, assay development team, and strategic marketing specialists to align analysis methods with assay requirements
  • Define key analyses for different NGS assays targeting oncology and/or infectious disease
  • Collaborate with bioinformatics scientists and technology team to integrate existing internally developed algorithms into proprietary and open source tools based NGS pipelines
  • Collaborate with analysts and programmers to develop bioinformatics analysis methods
  • Work with business analyst / software development team to define and develop technical and user requirements for analysis software – both internal and external
  • Collaborate with bioinformatics team to integrate development efforts for NGS products with the existing product portfolio


  • Ph.D. in Bioinformatics/Life/Physical/Computer Sciences
  • 4+ years of combined industry and post-doctoral work experience in NGS software and pipeline development and analysis (M.S. with 7+ years of relevant work experience will be considered)
  • Expert knowledge in one or more of the following languages: PERL, Python, R, C/C++
  • Experience working in a Unix / Linux development environment
  • Experience analyzing NGS data for clinical and research applications / assays utilizing novel and/or existing NGS analysis tools and methodologies
  • Experience developing NGS bioinformatics pipelines, algorithms, and tools
  • Experience in cancer genomics (knowledge of oncogenic pathways) and/or infectious disease genomics
  • Expert in navigating and extracting information from publicly available databases (NCBI, UCSC, COSMIC, etc.)
  • Familiarity with commonly used algorithms for alignment and variant calling (SNV, InDel, CNV, Fusion, etc.)
  • Experience analyzing and interpreting NGS data from tumor and/or liquid biopsy samples
  • Experience working with NGS bioinformatics teams

Additional Desirable Qualifications include:

  • Experience working with business analyst / software development teams to define user and software requirements for NGS analysis tools
  • Experience in developing database data-structures using MySQL, Postgres, Oracle, etc
  • Experience with cloud based software development


  • See benefits at NanoString
  • NanoString is an EOE
  • NanoString participates in E-Verify. E-Verify is a web-based system that allows an employer to determine an employee's eligibility to work in the US using information reported on an employee's Form I-9. The E-Verify system confirms eligibility with both the Social Security Administration (SSA) and Department of Homeland Security (DHS). For more information, please go to the USCIS E-Verify website.
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