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Scientist I (Tissue - High-Plex Microscopy for Cancer Biomarkers)

Job Summary:

NanoString is seeking a highly motivated and technology-savvy scientist, who will join R&D.  This position will have a key role on the development of a novel new spatial profiling technology, an approach for measuring expression levels of proteins and nucleic acids in a highly multiplexed manner in specific areas of tissues (a new paradigm in Digital Immunohistochemisty). The work is highly interdisciplinary and will involve working closely with biologists, hardware and software engineers, and external customers.  Successful candidate must be passionate about wet-lab driven experimentations to find innovative solutions to development hurdles.  Candidate must have strong analytical skills, strong oral and written communication skills, and strong track record of independent as well as collaborative research and development.

Essential Duties:

  • Take initiatives to conceive, design and carry-out hypothesis driven feasibility experiments to drive the development of the chemistry as well as inform the design of the hardware/software.
  • Strong understanding both theoretical and practical aspects of the experimental design
  • Drive wet-bench experimentation and subsequent data analysis/interpretation activities
  • Work interactively with biophysicists, nucleic-acid chemists, fluorescence imaging specialists, and hardware/software engineers

Requirements:

  • Ph.D. in immunology, cancer-biology, biochemistry, molecular biology, or related field.
  • 2+ years of industrial and/or post-doctoral work experience
  • Extensive experience with human immune-oncology
  • Extensive experience with Immunohistochemistry (IHC)
  • Strong wet bench and assay development skills related to consumable reagents development.
  • Experience with imaging and assays involving tissue preparations, especially FFPE (formalin fixed paraffin embedded) tissue.
  • Excellent verbal and written communication skills
  • Experience with protein detection methodologies, proteomics, multiplexed protein assays and handling antibodies
  • Experience with RNA and DNA sample preparation, genomics and a wide variety of nucleic acid protocols
  • High degree of computer literacy with frequently used software such as Microsoft Word, PowerPoint, Project Management, Excel, ImageScope.
  • Experience with client management skills

Additional Qualifications include:

  • R and python experience preferred
  • Experience in next generation sequencing is plus.
  • Experience with scripting and automation of laboratory equipment / microscopes for new assay workflow development
  • Experience with fluorescence-based detection technologies including single molecule detection
  • Experience with bright field and fluorescent microscopy applied to tissue and cellular imaging.

Other:

  • See benefits at NanoString
  • NanoString is an EOE
  • NanoString participates in E-Verify. E-Verify is a web-based system that allows an employer to determine an employee's eligibility to work in the US using information reported on an employee's Form I-9. The E-Verify system confirms eligibility with both the Social Security Administration (SSA) and Department of Homeland Security (DHS). For more information, please go to the USCIS E-Verify website.

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