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Scientist I (NGS Scientist for Digital Spatial Profiling)

Job Summary:

NanoString is seeking an NGS Scientist to join a dynamic, fast-paced team-oriented environment to develop novel Illumina library preparation methods for profiling RNA from formalin-fixed paraffin embedded (FFPE) samples.  This work will be developed in conjunction with NanoString’s recently announced Digital Spatial Profiling (DSP) technology, which allows precise spatial digital quantification of proteins and gene expression. The ideal candidate will be a highly skilled molecular biologist or nucleic acid chemist with experience or working knowledge in in situ hybridization, gene expression profiling, Illumina sequencing systems, and NGS data analysis.  You will design and execute advanced research and NGS experiments to demonstrate feasibility of innovative spatial gene expression technologies as well as contribute to the analysis of large complex NGS data sets.  You will participate in a larger cross-functional DSP team to meet internal and external deadlines to deliver high quality, robust new products.  A successful candidate for this role is a hands-on problem-solver in the lab with excellent analytical skills and strong oral and written communication skills. You will be both a strong individual contributor as well as a collaborative team member.  A track record of independent research and development in RNA-Seq is preferred.

Essential Duties:

  • Apply expert NGS knowledge and wet-bench skill to develop high-throughput NGS library preparation method for sequencing on Illumina systems
  • Design and carry-out experiments for fast development of prototype library procedures for feasibility testing in conjunction with DSP technology developers
  • Develop and evaluate innovative NGS assays for gene expression profiling in FFPE tissue
  • Optimize current NGS library preparation protocols for high quality and robust performance
  • Analyze large complex NGS data sets
  • Work interactively with biophysicists, nucleic-acid chemists, fluorescence imaging specialists, bioinformaticists, engineers, and hardware and software developers

Requirements:

  • Ph.D. in genomics, molecular biology or biochemistry with experience in assay development in an academic or industrial laboratory
  • 2+ years of combined industry and/or post-doctoral work experience in NGS using Illumina platforms, with large portion preferably dedicated to RNA-Seq or single-cell RNA-Seq (Ph.D work in this area will also be considered as relevant work experience)
  • Extensive hands-on, state-of-the-art molecular biology experience in nucleic acid analysis and manipulation, including DNA and RNA purification, amplification, hybridization, etc.
  • Working knowledge of DNA and RNA enzymology including polymerases, ligases, nucleases, modification enzymes, etc.
  • Solid understanding of standard NGS bioinformatic tools and/or experience in building NGS data analysis pipelines. 
  • Excellent skills in experimental design, implementation, troubleshooting, and data analysis
  • Must be detail oriented and highly motivated; independent yet enjoys working in a multidisciplinary, collaborative team environment
  • Able to work effectively under pressure to meet scheduled deadlines and to handle multiple activities simultaneously
  • Excellent oral and written communication skills

Other:

  • See benefits at NanoString
  • NanoString is an EOE
  • NanoString participates in E-Verify. E-Verify is a web-based system that allows an employer to determine an employee's eligibility to work in the US using information reported on an employee's Form I-9. The E-Verify system confirms eligibility with both the Social Security Administration (SSA) and Department of Homeland Security (DHS). For more information, please go to the USCIS E-Verify website.

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